Point-of-care testing devices providing medically relevant information are increasingly used by members of the public without any formal medical knowledge. As a result, these devices may be used in extremely different contexts of use by users with different knowledge bases, whether that was the original designers’ intent or not. W21C conducted out-of-the-box testing of a device for non-invasive blood hemoglobin measurement, and then tested the device’s potential with different user groups to create generic instructions.